Who ought to receive the benefits of research and bear its burdens? This is a question of justice, in the sense of “fairness in distribution” or “what is deserved.” An injustice occurs when some benefit to which a person is entitled is denied without good reason or when some burden is imposed unduly. As with all hard cases, the different claims covered by the principle of beneficence may come into conflict and force difficult choices.ģ. Whereas nonmaleficence is concerned with doing. Two general rules have been formulated as complementary expressions of beneficent actions in this sense: (1) do not harm and (2) maximize possible benefits and minimize possible harms. Beneficence is the principle that actions and practices are right insofar as they produce good consequences. Such treatment falls under the principle of beneficence.
Persons are treated in an ethical manner not only by respecting their decisions and protecting them from harm, but also by making efforts to secure their well-being. The judgment that any individual lacks autonomy should be periodically reevaluated and will vary in different situations.Ģ. The extent of protection afforded should depend upon the risk of harm and the likelihood of benefit. Some persons are in need of extensive protection. This principle can trace its origin back over 2,500 years to Hippocrates. Respect for the immature and the incapacitated may require protecting them as they mature or while they are incapacitated. It is commonly said that the first principle of medical ethics is do no harm. These principles are autonomy (informed choice), non-maleficence (do no harm), beneficence (do positive good), justice (equality and fairness) and fidelity (. To respect autonomy is to give weight to autonomous persons' considered opinions and choices while refraining from obstructing their actions unless they are clearly detrimental to others. In most cases of research involving human subjects, respect for persons demands that subjects enter into the research voluntarily and with adequate information.
The principle of respect for persons thus divides into two separate moral requirements: the requirement to acknowledge autonomy and the requirement to protect those with diminished autonomy. Respect for persons incorporates at least two ethical convictions: first, that individuals should be treated as autonomous agents, and second, that persons with diminished autonomy are entitled to protection. Three basic principles, among those generally accepted in our cultural tradition, are particularly relevant to the ethics of research involving human subjects: the principles of respect of persons, beneficence and justice. The expression " basic ethical principles" refers to those general judgments that serve as a justification for particular ethical prescriptions and evaluations of human actions.
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